Endocrine Abstracts

Introduction: Acromegaly is a rare disease caused by GH hypersecretion from a pituitary adenoma. However, accurate estimates of incidence and prevalence are scarce and not based on nationwide populations. It is well known that surgical cure may normalize mortality and improve morbidity but similar data are not available for patients receiving medical treatment.Method: We first validated the ICD-8 and ICD-10 diagnosis codes for acromegaly in The National ...

Introduction: Hyponatremia (serum sodium ≤135 mmol/l), the most common electrolyte disorder encountered, has been associated with increased mortality in patients with particularly cancer, heart failure, chronic kidney and liver disease. However, evidence of the clinical implications in broader populations is scarce, and uncertain due to confounding from preexisting disease. We aimed to examine the association between admission-hyponatremia and 30-day mortality in acute n...

Background: Cross-sectional studies in small and selected populations indicate a relatively high prevalence of incipient and/or subclinical Cushing’s syndrome (CS) in patients with type 2 diabetes (T2D), which could have therapeutic implications.Aim: To estimate the prevalence of CS in a large, unselected cohort of recently diagnosed T2D patients.Methods: A total of 384 consecutive out – patients with T2D diagnosed after ...

Objectives: There is limited knowledge of high-sensitivity C-reactive protein (CRP) levels among newly diagnosed T2D patients in the population-based setting, and of factors associated with elevated CRP.Methods: Measurements of CRP were performed in the first 1036 T2D patients in the nationwide DD2 project, enrolling new T2D patients from general practitioners and hospital specialist outpatient clinics. We examined the number of T2D patients within CRP t...

Objectives: Elevated levels of serum alanine aminotransferase (ALAT) have been linked with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), insulin resistance and the metabolic syndrome in type 2 diabetes (T2D) patients. We examined ALAT levels in newly diagnosed T2D patients, and the factors associated with such elevation.Methods: Measurements of ALAT were performed in 1025 (43% women and 57% men) new T2D patients enrolle...

Few population-based data exist on the prevalence of the metabolic syndrome (MS) its components, and its association with subclinical inflammation and insulin resistance among patients newly diagnosed with type two diabetes (T2D).We examined the MS according to IDF criteria by linkage primary data (waist circumference, fasting blood glucose, and high-sensitivity C-reactive protein (CRP)) with variables from the Danish diabetes database for adults (blood ...